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◇ medRxiv2026-08-30· health informatics

Forecasting glucose from CGM and sparse meal logs with a residual-gated multimodal transformer

J. Lee, S. Yao, L. Tang, X. Yu, M. C. Cheney, H. Lin, X. Zhang, D. Mukherjee, M. E. Walker, N. L. Spartano, H. Cheng

原始摘要(英文原文)· Original abstract
Forecasting glucose from continuous glucose monitoring in free-living settings is challenging because trajectories depend on endogenous dynamics and sparsely recorded meals. We developed $\our$, a multimodal transformer that produces a complete CGM-based forecast and then adds a gated, meal-informed residual correction. The correction is controlled by combined self-reported and CGM-derived evidence of meal presence, scaled per forecast horizon, allowing for dietary context to improve predictions without requiring meal records. We evaluated $\our$ in 1,752 adults without diabetes from the Framingham Heart Study. Participants wore Dexcom G6 Pro sensors and completed paired ASA24 dietary recalls. $\our$ achieved the lowest mean absolute error across forecast horizons, meal-state strata, and glucose ranges compared with long short-term memory, transformer, and GluFormer model architectures. It also improved prediction of postprandial peak glucose, time-to-peak, positive incremental area under the curve, and time in the 70--140~mg/dL range. Participant-level cross-validation confirmed generalization to unseen participants.
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