Enantioselective carboamination of olefins catalyzed by transition metals.

Enantioselective olefin carboamination is the simultaneous formation of C-N and C-C bonds across an alkene. This method represents a powerful strategy to build molecular complexity with up to two vicinal stereocenters in a single operation. Over the past two decades, transition metal catalyzed enantioselective olefin carboamination has been well-developed. Various elegant studies have employed this strategy to synthesise a series of amines or aza-heterocycles with stereocenters. Initially, reactions catalyzed by noble metals such as Pd and Rh were explored, followed by the development of enantioselective carboamination reactions using non-noble metals (Fe, Co, Ni, and Cu). In this review, we will discuss enantioselective olefin carboamination catalyzed by different transition metals and provide a detailed overview of the mechanisms involved.