Liangliang Zhang, Huilin Liu, Tomás G. Santiago, Rubén Martı́n
Herein, we disclose an enantioconvergent carbamoylation of racemic aziridines enabled by a dual catalytic strategy. The method offers a new entry point to highly enantioenriched β-amino amides from simple precursors and is characterized by its broad applicability, even with challenging combinations. Preliminary studies with well-defined nickel complexes support a scenario via carbamoyl organometallic intermediates.