Transition-Metal-Catalyzed Carbon-Carbon Cross-Coupling: Synthesis of α-Chiral Allylic Amines.

α-Chiral allylic amines represent a privileged structure in organic synthesis, catalysis, and other areas. Thus, the development of catalytic methods for straightforward and efficient construction of chiral allylic amines has been a longstanding interest in synthetic chemistry. In this context, transition-metal-catalyzed asymmetric carbon-carbon cross-coupling is evolving into an enabling and versatile platform for direct synthesis of α-chiral allylic amines. Thus, this review provides a comprehensive overview of recent advances in this dynamic area, highlighting key catalytic strategies and mechanistic insights for catalytic C─C bond-forming processes that underpin the streamlined synthesis of chiral allylic amine frameworks from easily available starting materials.