Risk of low-frequency ultrasound stimulation: Response to “Brain injury during focused ultrasound neuromodulation for substance use disorder”

We are writing to offer our perspective on the correspondence by Rezai et al.[1], disclosing a serious adverse event (SAE) incurred by low-intensity transcranial focused ultrasound stimulation (tFUS). Like others, we recognize the limitation in only providing the 90 W free-field power output in the initial report and commend the tFUS community for successfully pushing for the release of more detailed sonication parameterization, including mechanical index (MI) and intensity, to compare to the published record of safety of low-intensity tFUS[2].