Sophia Ohnemus, Linda Tillert, Roberta De Zio, Raluca-Andreea Tifrea, Andries Napo Leemisa, Simon Beyer, Peter Köhl, Viviane Timmermann, Franziska Schneider-Warme, Johannes Vierock
concentration during extended illumination. These changes are promoted by the large photocurrent amplitudes observed in WiChR-expressing cells and differ substantially among individual cells and across cell types, underlining the importance of the optogenetically targeted host system. Our model presents a framework for assessing and predicting WiChR photoresponses and will be useful for guiding the design of optimized stimulation protocols for future application of WiChR and other KCRs.