Modeling Changes in Erythrocyte Volume Depending on the Conductivity of Ion Channels.

We developed a physicomathematical model for estimating transmembrane potential and cell volume responses to changes in membrane permeability to cations. Numerical simulations demonstrated that the developed model allows high-sensitivity prediction of cell volume changes depending on physiologically acceptable deviations in the permeability of passive channels for Na+, Ca2+, and K+ ions.