Nessa Nessa, Ifmaily, Ronaldi Zacel
Corn silk (Zea mays L.) is known to have antioxidant activity which is thought to have potential in preventing kidney damage. This study was conducted to determine the activity of corn silk fraction as a nephroprotector in male white rats. This study used 5 groups of rats consisting of a negative control group only given 0.5% NaCMC suspension orally, a positive control group given gentamisin 80 mg/kgBW intraperitoneally, a treatment group of corn silk fraction doses of 200, 400, and 800 mg/kgBW, The treatment group was given a suspension of the fraction orally for 8 days, On the 3rd day, gentamisin induction was given intraperitoneally 1 hour after administration of the fraction until the 8th day of administration of the fraction. On the 8th day urine was collected for microscopic examination and on the 9th day blood was taken from the orbital vein of the eye to measure serum creatinine and urea levels. The average results of creatinine levels in groups 1 to 5 were 0.3; 1.35; 0.35; 0.5; 0.7 mg/dL. And the average urea results of groups 1 to 5 were 16; 32; 18; 18.5; 19.5 mg/dL, respectively. Data analysis was carried out using one-way ANOVA followed by Duncan's test, showing that the administration of corn silk fraction significantly affected creatinine and urea levels (p<0.05). Based on the results of the study, it was concluded that there was nephroprotective activity in the corn silk fraction with a dose variation of 200 mg/KgBW which was closest to the negative control group