Effect of Oral Supplementation of Kratom (Mitragyna speciosa Korth.) on Gastrointestinal Nematodes and Serum Lipid Peroxidation in Crossbred Saanen Goats.

The objective of this study was to compare fecal egg count (FEC) and serum malondialdehyde (MDA) concentration in naturally parasite-infected goats following administration of an anthelmintic drug and Mitragyna speciosa Korth. as the control and treatment groups, respectively. A total of 34 female goats were randomly allocated into two groups. The control group received albendazole at a dose of 15 mg/kg on the first day of the experiment. Then followed by a daily placebo until day 21. The treatment group was orally administered 5 g/head of dried Mitragyna speciosa Korth. daily for 21 days. Hematological parameters were evaluated on days 0 and 21, while blood biochemical parameters, including blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), were measured on day 0 and at 7-day intervals until day 35. Fecal egg count and serum MDA concentration were determined on day 0 and every 7 days until day 42. The results showed that plasma protein levels were significantly affected by time (p < 0.05) and group (p < 0.05), while red blood cell count was significantly influenced by time (p < 0.05). No significant group effects were observed for BUN, creatinine, AST, and GGT. However, AST showed a significant effect over time (p < 0.05). Hematological and blood biochemical parameters remained within physiological ranges in both groups, with no evidence of kratom-associated toxicity. Log2-transformed fecal egg counts per gram of feces (Log2-EPG) showed significant time and time × group interaction effects (p < 0.001 and p = 0.008, respectively). Fecal egg count reduction test (FECRT) showed significant time and time × group interaction effects (p = 0.009 and p = 0.013, respectively). Serum MDA was significantly lower in the kratom group only at day 7 (p < 0.05). In conclusion, Mitragyna speciosa Korth. supplementation did not significantly reduce fecal egg count compared to conventional anthelmintic treatment but demonstrated a transient effect on oxidative stress, as indicated by changes in serum MDA concentration.