Antonios I. Christou, Georgia D. Kalfadeli, Flora Bacopoulou
BACKGROUND/OBJECTIVES: In recent years, improvements and innovative treatments in pediatric cancer have significantly increased survival rates, but challenges in both cognitive and psychosocial development in children remain significant. This review applies a comprehensive framework to evaluate psychosocial interventions in pediatric populations, offering novel insights into intervention strategies and their effectiveness across diverse contexts. METHODS: A systematic search was conducted in the PubMed, Scopus, PsycINFO, and Web of Science databases for the period 2000-2024. Controlled studies, systematic reviews, and qualitative studies examining psychosocial interventions for children and adolescents with cancer or survivors were included. Quality assessment was performed using the RoB2 tool, and data were analyzed using narrative synthesis by age group and type of intervention. RESULTS: Studies have shown that developmentally targeted interventions, such as therapeutic play, cognitive-behavioral therapy, and school reintegration programs, improve emotional regulation, cognitive functioning, and social adjustment in children with cancer. However, the heterogeneity of the samples and the variety of measurements limit the generalizability of the results. CONCLUSIONS: Integrating a developmental perspective into the design of psychosocial interventions can enhance their effectiveness and sustainability in pediatric oncology. Future research should focus on long-term, culturally sensitive programs and their implementation in clinical practice.