Peng Deng, Zhihong Ling, F Fang, Jishi Ruan, Chuanjun Yang, Rong Hu, Jing Zhou, Peizheng Xiong
MXene, a novel class of two-dimensional nanomaterials, has garnered significant attention for antitumor drug delivery due to its exceptional properties, including high specific surface area, excellent photothermal conversion efficiency, and tunable surface chemistry. Given the limitations of traditional cancer therapies, such as systemic toxicity and poor tumor targeting, MXene-based nanocarriers offer a promising solution. This review summarizes the intelligent responsive nano-drug delivery system constructed with MXene nanomaterials as a drug carrier material, as well as the research progress of endogenous stimulation (pH value and redox microenvironment), exogenous stimulation (photoheat and ultrasound), and multistimulus-responsive MXene nanomaterials. The aim is to provide valuable insights and inspirations for the further development of effective and safe MXene nanomaterials with antitumor properties.