Synergistic effects of herbal extracts and nanoparticles in skin damage repair: A comprehensive review.

OBJECTIVE: Today, applying herbal extracts to treat skin damage has become widespread and it is supported by numerous studies that confirmed their effectiveness. Due to fewer side effects, diversity of active compounds in them, and lower costs, herbal extracts are an important therapeutic method for skin lesions. Additionally, nanoparticles are important for stimulating the body's ability to recover and treat wounds. MATERIALS AND METHODS: This review article aims to evaluate how combining herbal extracts with nanoparticles and advanced drug carriers (like liposomes and nanofibers) creates synergistic effects that enhance the treatment of bacterial skin infections and wounds. By improving bioavailability, targeting delivery, and reducing required dosages, these formulated combinations offer a more effective, faster-healing, and potentially safer alternative to conventional therapies. RESULTS: Based on the discussed studies, therapy using a combination of medicinal herbs and nanotechnology increases the effectiveness of treatment, accelerates recovery, and decreases the use of each material, thereby reducing the toxicity of each in infection and skin damage treatment. CONCLUSION: This review conclusively demonstrates that the strategic formulation of herbal extracts with nanoparticles and advanced drug carriers-such as liposomes, nanofibers, and polymeric nanoparticles-unlocks unprecedented synergistic potential for treating bacterial skin infections and accelerating wound and burn healing. By enhancing bioavailability, enabling targeted delivery, and reducing therapeutic doses (thereby minimizing toxicity), these nano-herbal hybrids represent a paradigm shift toward safer, faster, and more cost-effective regenerative therapies that can combat antibiotic resistance and revolutionize modern dermatological care.