Mark Katson, Teddy Lazebnik, Meirav Har-Even, Maxim Glebov, Fawzia Naamnih, Alon Sinai, Maria Nassar, Inna Senderova, Marius Constantinescu, Lior Lev Tov, Vered Aharonson, Ilana Schlesinger
Objective measures of tremor could improve assessment of response to magnetic resonance-guided focused ultrasound (MRgFUS) for essential tremor in practice, but it is unclear whether image-derived metrics from spiral drawings reflect clinician judgment. In this study, we analyzed 410 spiral-drawing observations from 106 patients with essential tremor undergoing MRgFUS thalamotomy and compared two recent computer-vision measures with a simple geometric metric (total line length) against an ordinal clinical rating scale for tremor spiral scores using ordered logistic mixed-effects models. Only line length independently tracked worse clinician-rated severity (odds ratio(per 1 mm) 1.017, p < 0.01), whereas the two image-based scores showed no significant association. The model captured the expected treatment signature, with marked post-procedural improvement confined to the treated hand. These findings suggest that low-complexity interpretable features may better approximate clinically meaningful tremor severity than more elaborate image-processing metrics and support further validation against functional outcomes.