Radheshyam Meher, Gopal K. Patidar
Abstract Background and Objectives Vasovagal reactions (VVRs) are the common donor adverse reaction, especially in young and first‐time donors, affecting donor return. Despite evidence‐based physiological and psychological mitigation strategies (MSs), their awareness and implementation remain variable. This study aimed to assess the awareness and practice of VVR MSs across licensed blood centres in India. Materials and Methods A cross‐sectional online survey was conducted between January and March 2025. A pre‐validated questionnaire was distributed via a Google Form link. Data included demographic details of respondents, centre type, annual collection and voluntary donors. It was also focused on awareness, types and usage of VVR MSs. Data were analysed using descriptive statistics, and associations were tested using χ 2 and logistic regression. This survey was reported in accordance with the Checklist for Reporting Results of Internet E‐Surveys (CHERRIES) guidelines. Results Of 4153 blood centres, 439 were included in the final analysis, having fulfilled the inclusion criteria. Among them, 370/439 (84.3%) were aware of VVR MSs, while only 298/439 (67.9%) implemented them. Water/fluid ingestion was the most common physiological strategy (254/268, 94.8%), followed by applied muscle tension (110/268, 41.1%). Among psychological strategies, primarily audiovisual distraction combined with psychosocial support was reported by 143/210 (68.1%) centres. Of the 298 centres, 213 (71.5%) offered special attention to high‐risk donors, 205 (68.8%) focused on delayed VVR prevention and 132 (44.3%) had dedicated counsellors. Conclusion Despite good awareness, implementation of VVR MSs in Indian blood centres remains inconsistent. Nationwide policy, awareness programmes and structured training could promote uniform, evidence‐based donor care and improve donor safety and retention.