Xinyue Zhang, Guirong Xu, Liwei Zhao, Ye Tao, Jiawei Zhang, Cameron E F Clark, Yangyi Hao, Zhijun Cao, Shengli Li, Wei Wang
Genome-resolved methylomics uncovers the first DNA methylation atlas of the dairy cow rumen microbiome. Microbial DNA methylation profiles diverge between low- and high- methane-emitting dairy cows despite limited taxonomic differences. Differential methylation is linked to transcriptional variation in genes involved in carbon metabolism, hydrogen utilization, and methanogenesis.