Angelina Kravcik, Jason Zelt, Stephen Kravcik
Piperacillin-tazobactam is a generally well-tolerated broad-spectrum antibacterial. Mild hypokalemia may occur with piperacillin-tazobactam therapy as a result of increased renal potassium losses. Severe hypokalemia is rare. We report here a case of very severe hypokalemia during piperacillin-tazobactam therapy, refractory to aggressive potassium replacement.