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◆ Chemical communications (Cambridge, England)2026-09-23

Pd-catalyzed cascade γ-C(sp3)-H activation/cyclization of aliphatic amines with allyl electrophiles: access to δ-vinyl pyrrolidines.

Anita Sahoo, Madhab Barman, Priya Patra, Tharmalingam Punniyamurthy

原始摘要(英文原文)· Original abstract
Sequential Pd-catalyzed auxiliary-assisted γ-C(sp3)-H alkenylation and cyclization of N-protected amines with allyl electrophiles has been accomplished to furnish optically active δ-vinyl pyrrolidines that are privileged cores in diverse bioactive molecules and natural products. The diastereoselectivity, functional group diversity and late-stage modifications of the natural products are the important practical features.
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Pd-catalyzed cascade γ-C(sp3)-H activation/cyclization of aliphatic amines with allyl electrophiles: access to δ-vinyl pyrrolidines. — 科研速览 Science Skim