Zhang Chen, Kexu Dai, Dong-Xiao Jiang, Yongqiang Wang, Xiaokang Long, Jinjin Chen, Zhen Wang, Yao-Fu Zeng
A mild and efficient photoredox-catalyzed trifluoroethoxyfluorination of alkenes is reported. Notably, by simply switching the halides, the reaction system can be readily steered toward tunable trifluoroethoxychlorination or trifluoroethoxybromination. The synthetic practicality of this approach is further substantiated through its application to the late-stage modification of alkene-containing natural products and pharmaceuticals.