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◆ Chemical Communications2026-01-01· Aromatization

Synthesis of thieno[2,3- <i>b</i> ]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes

Sk Jubayar Ahashan, Kousik Maji, Syed Ramizul Kabir, Jyotirmayee Dash

原始摘要(英文原文)· Original abstract
a Lawesson's reagent-mediated thiocarbonyl Cloke-Wilson rearrangement of spiro donor-acceptor cyclopropyl oxindoles, followed by oxidative aromatization under open-air conditions. The reaction proceeds smoothly under mild conditions, tolerates a range of aryl substrates, and can be performed on a synthetically relevant scale. Control experiments and DFT studies indicate a stepwise rearrangement pathway in which aerial oxygen promotes a barrier-less aromatization driven by aromatic stabilization. This work demonstrates the versatility of donor-acceptor cyclopropanes as efficient building blocks for the construction of sulfur-containing fused heteroaromatic frameworks.
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Synthesis of thieno[2,3- <i>b</i> ]indoles by Cloke–Wilson rearrangement of spiro donor–acceptor cyclopropanes — 科研速览 Science Skim