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◆ Organic Letters2026-02-07· Chemistry

Tandem Nitration-Cyclization-Rearrangement of Indole-Tethered 1,6-Enynes To Access NO <sub>2</sub> -Featured Heterocycles

Zexuan Liu, Qinqin Yan, Huaqing Liu, Jingyi Chen, Xueli Wang, Lijun Li, Zhong-Quan Liu, Zejiang Li

原始摘要(英文原文)· Original abstract
as the carbonyl oxygen source and low-cost TBN as the nitro reagent. Meanwhile, the stable indole skeleton could smoothly undergo rearrangement to access dicarbonyl fused cycles. In addition, complex molecular transformation and scaled-up experiments examined the application of this tandem system. Finally, diverse mechanistic studies (including isotopic labeling, radical inhibition/capturation experiments) explored the reaction pathway.
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Tandem Nitration-Cyclization-Rearrangement of Indole-Tethered 1,6-Enynes To Access NO <sub>2</sub> -Featured Heterocycles — 科研速览 Science Skim