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◆ Nature Communications2025-11-24· Iontophoresis

pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis

Wangwang Zhu, Haixia Yu, Wen‐Jun Li, Xi Li, Hao Zheng, Chengcheng Li, Xingguo Zhang, Chenxi Jin, Mutian Wang, Jiaqi Hou, Youhao Liu, Yuxiao Ma, Zhongxu Zhou, Miao Deng, Peng Guo, Mingzhen Li, Zhenqiang Song, Zhihua Pu, Dachao Li

原始摘要(英文原文)· Original abstract
movement and the skin recovery ability. Here, we investigated how the skin surface pH affected RI, theoretically and experimentally; and developed a wearable device and a calibration method to enable accurate non-invasive ISF glucose detection, accordingly. The result showed that glucose prediction accuracy was markedly improved, with mean absolute relative difference (MARD) decreased from 34.44% to 14.78% across both healthy and diabetic volunteers.
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pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis — 科研速览 Science Skim