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◆ JACS Au2026-04-09· Chemistry

Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins

Hang Zhou, Yan Sun, Rui Xu, Tao Chen, Liu Gao, Guofeng Zhao, Junliang Zhang, Yidong Wang

原始摘要(英文原文)· Original abstract
) bond activation of benzosilacyclobutene. This method exhibits a robust substrate scope, accommodating allenes with alkyl, alkenyl, aryl, silyl, alkoxy, and complex bioactive substituents to deliver enantioenriched functionalized silatetralins. Moreover, the protocol provides direct access to valuable exocyclic methylene-containing silatetralins, serving as versatile intermediates for further synthetic diversification.
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Palladium-Catalyzed Enantioselective [4 + 2] Annulation with Allenes: Direct Access to Chiral Silatetralins — 科研速览 Science Skim