Yuzhen Li, Hongyu Wang, Xiaofan Chen, Ruwendan Deng, Yuqiao Zhou, Weidi Cao, Xiaoming Feng, Xiaohua Liu
Asymmetric radical addition to 1,3-enynes represents an efficient strategy for the construction of chiral allenes. Current methods typically rely on prefunctionalized radical precursors and electron-rich 1,3-enynes. Herein, we report a photoinduced enantioselective 1,4-radical hydroalkylation of 2-acyl 1,3-enynes with inert C(sp3)-H compounds. Synergistic catalysis merging a quinone-based hydrogen atom transfer photocatalyst with a chiral N,N'-dioxide/Sc(III) complex was exploited to enable the straightforward synthesis of chiral allenes in high yield and enantioselectivity.