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◆ European Journal of Organic Chemistry2026-05-24· Chemistry

Copper/Photoredox‐Catalyzed Asymmetric 1,4‐Arylcyanation of 1,3‐Enynes to Access Chiral Tetrasubstituted Allenes

Xin‐Yu Peng, Wangqin Ji, Tao‐Yan Lin

原始摘要(英文原文)· Original abstract
A method for the photoredox/copper dual‐catalyzed asymmetric 1,4‐arylcyanation of 1,3‐enynes via a radical pathway has been established, in which Ar‐DBT + salts serve as aryl radical precursors, affording diverse chiral tetrasubstituted allenes with moderate enantioselectivity and high chemo‐ and regioselectivity. This strategy operates under mild conditions, exhibits broad substrate scope with excellent functional group tolerance, and delivers chiral tetra ‐substituted allenes in one step using both electron‐rich and electron‐deficient aryldibenzothiophenium (Ar‐DBT + ) salts.
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Copper/Photoredox‐Catalyzed Asymmetric 1,4‐Arylcyanation of 1,3‐Enynes to Access Chiral Tetrasubstituted Allenes — 科研速览 Science Skim