Yarema Galushchak, Yeva Shevchenko, Andrii Slobodianyk, Roman Kotsiubchyk, Péter Spránitz, Kristof Hegedüs, Tibor Soós, Svitlana Bondaruk, Galeb Al-Maali, Pavel K Mykhailiuk
N-Boc azetidinone smoothly reacts with secondary amines and benzotriazole at room temperature to provide Katritzky benzotriazole adducts. The subsequent addition of Grignard reagents afforded amino azetidines. The reaction is scalable (up to 100 g) and can be used for the preparation of other functionalized small rings: amino oxetanes and cyclobutanes.