Enes Dasdemir, Ivo Veletić, Christopher Ly, Andres Quesada, Christopher D. Pacheco, Fatima Zahra Jelloul, Pâmella Borges, Sreyashi Basu, Sonali Jindal, Zhiqiang Wang, Alexander J. Lazar, Khalida M. Wani, Dinler A. Antunes, Patrick K. Reville, Preethi H. Gunaratne, Robert J. Tower, Padmanee Sharma, Hussein A. Abbas
-differentiation signals concentrated in AML-infiltrated regions; committed-like AML cells resided in inflammatory niches distant from trabeculae, while primitive-like cells localized near the endosteal niche. GeoMX digital spatial profiling and Opal multiplex fluorescent immunohistochemistry provided orthogonal validation. Overall, our study offers a valuable multimodal resource for exploring AML spatial biology with potential applications in other BM malignancies.