Pulmonary aspergilloma due to Aspergillus flavus in an immunocompetent patient from Northeast Iran: A case report.

A 27-year-old man presenting with cough, dyspnea, and an abnormal chest radiograph was clinically suspected of having a pulmonary aspergilloma. Histopathological examination of the resected lung tissue demonstrated a dense aggregation of branching, septate hyphae, and partial β-tubulin gene sequencing identified the isolate as Aspergillus flavus. Antifungal susceptibility testing showed the lowest MIC for posaconazole (0.125 μg/mL) and the highest for amphotericin B (4 μg/mL) and 5-fluorocytosine (>64 μg/mL). The patient was discharged after a 16-day hospitalization with complete clinical recovery and was prescribed oral itraconazole for continued outpatient management.