Changes in nasal and oral microbiota composition during a 10-day decolonization course with mupirocin and povidone-iodine: A real-world case series

Microbiota composition influences methicillin-resistant S aureus (MRSA) colonization, yet the contribution of the oral microbiota and the impact of decolonization approaches remain insufficiently explored. In this study, we report microbiota shifts in 3 adults with oral MRSA colonization who underwent decolonization treatment, including povidone-iodine. Relative bacterial abundances fluctuated across oral sites and over time, indicating distinct ecological responses to treatment. These findings improve our understanding of how the oral microbiota may affect MRSA decolonization and highlight the importance of oral microbial dynamics to guide more personalized and effective strategies.