Chih-Fang Lai, Gardenia Esam, Yu‐Chien Lin, Ren-Jei Chung
Abstract Investigating the pivotal role of Matrix Metalloproteinase-1 (MMP-1) unveils its significant impact on the skin aging process, a complex interplay of intrinsic genetic factors and external environmental stressors, including photoaging. As a key enzyme in collagen degradation, MMP-1 significantly influences the loss of skin integrity and elasticity over time. Delving into the architecture and role of MMP-1, as well as the regulatory mechanisms controlling its activity, is crucial for devising effective anti-aging strategies. The potential of MMP-1 inhibitors, including small molecules, peptides, and natural compounds, is emphasized for their ability to diminish aging signs and enhance skin appearance. Moreover,the application of MMP-1 inhibitors in chronic wound healing illustrates their extensive therapeutic capabilities beyond anti-aging. The compilation of current studies highlights the urgent need for innovative MMP-1 inhibitors and combination therapies to improve clinical outcomes and safety profiles. Through the synthesis of a series of studies, it is hoped to pave the way for groundbreaking advancements in anti-aging strategies, making significant contributions to the fields of dermatology and cosmeceutical sciences.