Joanna Czerwińśka, Agnieszka Owczarczyk‐Saczonek
Matrix metalloproteinases (MMPs) are endopeptidases that help maintain tissue homeostasis. Dysregulation of MMP secretion or activity, along with issues in their natural regulators, contributes to the development of many disorders, including autoimmune skin diseases. This article provides a comprehensive review of current research on MMP biology, their physiological functions, and disease-specific evidence in dermatology. Based on available English-language studies, we discuss key papers with important findings and the latest systematic reviews from PubMed. Additionally, a comparison, synthesis, and summary of reported results are included to highlight the specific role of MMPs in dermatology and to identify research gaps that need to be addressed for developing and using MMPs as potential biomarkers in skin disease pathophysiology.