Min Wang, Shan Huang, Guangmin Liao, Huangyue Yu
ABSTRACT This review provides a comprehensive overview of the synthesis methods for different types of polysulfones, including bisphenol A‐based polysulfone (PSF), polyethersulfone (PES), and polyphenylsulfone (PPSU). Conventional polycondensation techniques, including solution‐phase and melt‐phase processes, are critically analyzed alongside innovative synthetic approaches such as vortex fluidic‐mediated polymerization, phase‐transfer catalyzed polycondensation, and AB‐type monomer self‐polycondensation, which collectively enable precise control over macromolecular architectures while enhancing production efficiency. Furthermore, this review highlights significant advancements in sustainable polymer chemistry, particularly the development of bio‐based synthetic routes utilizing renewable monomer feedstocks to mitigate dependence on petrochemical precursors. Special emphasis is placed on advanced functionalization strategies, including surface modification and copolymerization techniques, which impart tailored properties such as enhanced hydrophilicity, tunable ion‐exchange capacity, and optimized biocompatibility—critical parameters for next‐generation filtration membranes and implantable medical devices. These scientific and technological innovations underscore the pivotal role of green chemistry principles and novel polymerization paradigms in advancing the field of high‐performance polysulfones, addressing the escalating demand for environmentally benign materials with superior engineering characteristics.