Xile Deng, Feiying Zhu, Heng Qiao, Wenjie Shangguan, Qin Yu, sandeep sharma, Vijayakumar Shanmugam, Yanan Deng, Yudan Wu, Pengyue Zhao, Ullah Farman, Lidong Cao, Shuo Yan, Zhichao Dong, Lianyang Bai
Nano-pesticides are driving a paradigm shift toward sustainable plant protection. This review systematically synthesizes recent advances across four interconnected domains: (i) intelligent formulation design for targeted delivery and controlled release; (ii) interfacial behavior regulation to enhance foliar deposition; (iii) multi-omics elucidation of synergistic efficacy and molecular interactions; and (iv) environmental fate management, including risk mitigation and microbiome remediation. By integrating these multiscale innovations, the field is advancing nano-enabled crop protection from laboratory research toward field application. Collectively, this convergence provides a scientific foundation and interdisciplinary roadmap needed to build next-generation agricultural systems that are resource-efficient and ecologically compatible.