Direct Mechano-Catalytic Synthesis of Amides Using Brass Balls via Cross-Coupling of Isocyanides With Arylboronic Acids or in Situ Generated N-Aryl-Pyridinium Salts.

Given the importance of amides as valuable biological molecules and pharmaceutics, there is a surge of synthetic methods to access amides adopting the solvent-free synthetic routes. Herein, we report an alternative approach for the mechanochemical synthesis of N-alkyl/aryl amides via brass balls catalyzed cross-coupling between isocyanides and anilines or arylboronic acids mediated by pyridinium tetrafluoroborate (Pyry-BF4) or TEMPO. Adopting a wide range of substrate scope, the present protocol offers a straightforward synthetic access to N-alkyl/aryl amides in good to excellent yields in short reaction times.