Alpikwangsides A-C, three previously undescribed compounds isolated from the rhizomes of Alpinia kwangsiensis and their NO inhibitory activity.

Three previously undescribed compounds, alpikwangsides A-C (1-3), together with 10 known compounds (4-13), were isolated from the rhizomes of Alpinia kwangsiensis (Zingiberaceae). Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS data, and the absolute configuration of compound 3 was assigned based on ECD analysis. Coronarin G (6) is reported from the genus Alpinia for the first time, whereas pahangensin B (7) is identified for the first time from this species. Biological evaluation showed that compounds 1-3, 7, and 8 inhibited LPS-induced NO production in RAW264.7 cells, with IC50 values ranging from 22.17 to 46.31 µM, compared with the positive control dexamethasone (IC50 = 12.64 µM).