Leucosposins A-E, five new glycolipids isolated from the Antarctic fungus Leuconeurospora sp. CPCC 401603 and their antimicrobial activities.

Five new glycolipids, leucosposins A-E (1-5), were isolated from fungus Leuconeurospora sp. CPCC 401603, collected from seawater in the Fildes region of Antarctica. Their structures and absolute configurations were elucidated by spectroscopic analyses including HRESIMS, IR, and NMR data, as well as ECD spectra. This study represents the first report on the chemical constituents of genus Leuconeurospora. Compounds 1-5 exhibited significant antifungal activities against Candida albicans ATCC 10231 with MIC values in the range of 1-8 μg/mL. Compounds 1 and 3 displayed moderate antibacterial activities against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212. These findings not only expand the chemical diversity of genus Leuconeurospora, but also provide new lead compounds for antifungal therapeutic strategies.