Enzyme‐Inspired Hydrogen‐Bonded Organic Frameworks for Synergistic Capture, Detection, and Degradation of Nerve Agent Simulants

Nerve agents (NAs), a class of highly toxic organophosphorus (OP) compounds, pose a significant threat to global security. The development of integrated protective materials that can simultaneously capture airborne OPs, detect, and degrade them remains a formidable challenge. Inspired by lipase's specific binding to OPs, a biomimetic hydrogen-bonded organic framework (HOF) is developed, FDU-HOF-5. It achieves highly efficient and selective adsorption of a sarin simulant, diethyl chlorophosphate (DCP), by combining size exclusion with molecular recognition via specific N─P bond formation, effectively distinguishing DCP from various OP analogues. Upon adsorption, the material responds within 5 s, enabling bimodal identification via a visual color change (yellow to red) and a fluorescence signal (99.7% quenching, 75 nm redshift). The adsorbed DCP is then self-drivenly hydrolyzed into non-toxic products by environmental moisture, achieving 91.5% degradation efficiency. Utilizing the solution processability of HOFs, functional textiles that show an immediate color change upon DCP exposure are produced. This work establishes a rational design strategy for multifunctional HOF systems that synergistically integrate capture, detection, and degradation for effective threat mitigation.