Alginate Beads Embedded with Metal–Organic Framework Particles for Solid-Phase Detoxification of Organophosphate under Ambient Conditions

Zirconium-based metal-organic frameworks (Zr-MOFs), endowed with periodic Lewis-acidic nodes, have emerged as highly promising catalysts for the hydrolytic detoxification of organophosphorus nerve agents. However, their intrinsic powder form and dependence on liquid water during catalysis severely limit their applicability in practical protective platforms. Herein, we present the construction of composite beads by integrating Zr-MOF catalysts with an alginate matrix, enabling the rapid solid-phase degradation of the nerve agent simulant dimethyl-4-nitrophenyl phosphate (DMNP) under ambient conditions. In this design, MOF-808 particles were incorporated within the alginate network, supplying abundant active sites for catalytic hydrolysis, while the alginate matrix maintained moisture retention and generated a mildly alkaline microenvironment conducive to the hydrolytic reaction. Benefiting from this synergistic configuration, the resulting composite beads exhibit outstanding catalytic efficiency and remarkable reusability for solid-phase DMNP degradation under ambient conditions, surpassing the performance of most previously reported Zr-MOF-based catalytic materials.