Straightforward Preparation of Polyurethane‐Based Biomaterials with Dual Antibacterial and Anti‐Adhesive Properties for Long‐Lasting Catheter Applications

Abstract Catheter‐associated infections are a major concern in hospitals, leading to both life‐threatening for the patients and a high cost for society. The development of a straightforward and industrial route to make an antibacterial catheter is thus worthwhile. This study demonstrates that the use of 2 wt.% of an antibacterial MeI‐quaternized poly(butyl methacrylate–block– N,N ‐dimetylaminoethyl methacrylate) P(BMA‐ b ‐DMAEMA) copolymer in combination with 2 wt.% of an antiadhesive poly(butyl methacrylate– block –poly(ethylene glycol) methyl ether methacrylate) P(BMA‐ b ‐PEG x MA) copolymer (with x the molecular weight of the PEG) as additives during the extrusion of the polyurethane matrix is an efficient method to produce antibacterial and antiadhesive PU materials without loss of activity after exposure to biologic media. The addition in the formulation of the antiadhesive copolymers enables protecting the surface from passivation and then to keep the contact possible between the bacteria and the antibacterial material. The antibacterial activity of the materials against E. coli and S. aureus is then preserved even after exposure to albumin, plasma, intralipids, or gastric acids. The prepared biomaterials also present no toxicity and are able to limit E. coli biofilm formation. Based on these results, this methodology can be realistically envisioned to elaborate long‐lasting venous or enteral catheters.