Jiaying Liao, Sin‐Yi Pang, Jianhua Hao
ABSTRACT MXenes, a family of two‐dimensional transition metal carbides and nitrides, have garnered significant attention in multifunctional sensing electronics due to their unique properties and versatile functionalization strategies. Despite rapid advancements in MXene‐based sensing materials, a comprehensive understanding of the role of multi‐scale interface engineering in designing MXene‐based multifunctional sensory systems with diverse sensing functionalities remains lacking. In this review, the recent advances of multi‐scale interface engineering technologies applied to MXene‐based multifunctional sensors and the advanced signal processing technologies for building intelligent sensory systems are reviewed. Specifically, the multi‐scale interface engineering strategies that endow MXene‐based multifunctional sensors with multiple sensing capabilities, superior sensing performance, and system compatibility are systematically analyzed. We further highlight the latest progress of data processing technologies for achieving seamless integration of perception, storage, and processing in a single sensory system. Finally, the opportunities and challenges faced by MXene‐based multifunctional sensory systems are discussed. This review will provide an in‐depth perspective on interface‐engineered MXenes for advanced multifunctional sensors and outlines prospects for next‐generation MXene‐based multifunctional sensory systems.