Weaponizing Ground Truth: Data Poisoning Attacks by Exploiting Boundary Misalignment Between Antivirus Software and Learning-Based Detectors

Machine-learning (ML)-based malware detectors are commonly trained using labels obtained from antivirus (AV) engines and aggregation services (e.g., VirusTotal). This practice assumes AV-generated labels provide reliable supervision. However, small byte-level modifications can substantially alter AV verdicts while leaving the representations perceived by downstream ML detectors largely unchanged, producing label-feature inconsistencies that can contaminate training datasets and create poisoning opportunities for ML-based malware detection. We present Bi-Iocane, a black-box poisoning framework that exploits the reliance of malware-labeling pipelines on AV-generated labels. Bi-Iocane identifies AV-sensitive bytes and modifies them to induce label changes. It rewrites such bytes in malware to obtain benign labels (evasion-oriented poisoning) and injects malware-associated byte patterns into benign software to obtain malicious labels (defamation-oriented poisoning). These poisoned samples and their lightly modified variants corrupt training data and cause selected targets to be misclassified. We evaluate Bi-Iocane with 13 AV engines simulating AV aggregation services and eight ML detectors. For 30 malware and 30 benign clean targets, Bi-Iocane combines AV-specific manipulations to generate malware-to-benign and benign-to-malware poisoned samples whose all tested AV-based labels are flipped. After these poisoned samples and variants are used for downstream training, the resulting ML models misclassify 92.08% of the original clean targets on average with only a 0.06\% poisoning budget per target. Meanwhile, the poisoned models largely preserve clean-set performance, and six evaluated poisoning defenses show only limited mitigation. VirusTotal evaluation further confirms practical defamation risk and reveals potential evasion risk in real-world AV-to-ML labeling supply chains.