Dominic Theodore, Nita Bhatt
Sensory impairments, including visual and auditory loss, are common across the lifespan and are increasingly recognized as risk factors for psychiatric disorders, particularly psychosis. Evidence suggests that disruptions in sensory processing, multisensory integration, and self-other signal differentiation may contribute to cortical disorganization overlapping with mechanisms implicated in psychotic illness. The psychiatric consequences of sensory impairment are influenced by chronicity and timing of onset, with congenital vs acquired loss conferring differing risks and clinical presentations. Communication barriers represent a major source of morbidity and diagnostic error, often leading to misinterpretation of symptoms as psychosis, negative symptoms, or noncooperation. This article reviews current literature on the relationship between sensory impairment and psychosis and highlights critical gaps in clinical guidance. Through illustrative case vignettes, we demonstrate common diagnostic pitfalls and propose practical strategies for assessment, including ensuring adequate communication, adapting mental status examinations to patient limitations, and carefully evaluating hallucinations and mutism in the context of sensory loss. Attention to these factors is essential to avoid misdiagnosis, improve patient-clinician communication, and reduce healthcare disparities experienced by individuals with co-occurring sensory and psychiatric conditions.