Matthew E Lehrack, John Daliva, Nadir E Eltahir, Ronald Chang, Aftab Qadir
Statins are among the most widely prescribed medications for hyperlipidemia, with drug-induced liver injury (DILI) being a rare adverse event. Here, we report a case involving a 69-year-old female patient who developed fulminant liver failure following an overdose of rosuvastatin. The patient had ingested 60 tablets of rosuvastatin 20 mg over the one-week period prior to hospital admission, mistakenly believing it was her pain medication. This acute high-dose exposure far exceeded recommended dosing and resulted in fulminant hepatitis and multiorgan failure. Despite comprehensive critical care, including advanced supportive and rescue interventions, the patient's condition deteriorated, and she did not survive. This underscores the potential lethality of statin overdose and the importance of medication safety, early recognition, and prevention strategies.