Fetal and Neonatal Alloimmune Thrombocytopenia in the Middle East: A Confirmed Case Highlighting Immunogenetic Diversity and Evidence-Based Neonatal Management.

We report a confirmed case of fetal and neonatal alloimmune thrombocytopenia (FNAIT) in a preterm Arab neonate born to a mother with a previously affected pregnancy. Antenatal management consisted of weekly intravenous immunoglobulin initiated at 16 weeks of gestation. Following delivery, the infant developed severe thrombocytopenia with a nadir platelet count of 25 × 10⁹/L but showed no evidence of intracranial hemorrhage. Treatment with two platelet transfusions followed by intravenous immunoglobulin resulted in a rapid recovery of platelet counts and an uncomplicated clinical course. This case highlights successful evidence-based antenatal and neonatal management of recurrent FNAIT in a Middle Eastern family and adds to the limited regional literature on immunogenetically confirmed cases.