Two Cases of Posner-Schlossman Syndrome With the Detection of Human Herpesvirus 6 DNA in the Aqueous Humor.

Posner-Schlossman syndrome (PSS) is one of the disorders characterized by the acute elevation of intraocular pressure (IOP). Because cytomegalovirus (CMV), varicella-zoster virus (VZV), and herpes simplex virus (HSV) have been detected in the aqueous humor of patients with PSS, a viral etiology has long been suspected. We encountered two patients with PSS in whom a polymerase chain reaction (PCR) analysis of aqueous humor detected human herpesvirus 6 (HHV-6) DNA. Both patients presented with elevated IOP and anterior chamber inflammation. Treatment with topical betamethasone and topical ganciclovir resulted in the normalization of IOP and the resolution of anterior chamber inflammation. Previous reports have suggested an association between uveitis and HHV-6 infection. Therefore, HHV-6 may also play a role in the pathogenesis of Posner-Schlossman syndrome.