Michael W Reimann, Sirio Bolaños‐Puchet, Jean-Denis Courcol, Daniela Egas Santander, Alexis Arnaudon, Benoît Coste, Fabien Delalondre, Thomas Delemontex, Adrien Devresse, Hugo Dictus, Alexander Dietz, András Ecker, Cyrille Favreau, Gianluca Ficarelli, Mike Gevaert, Joni Herttuainen, James B. Isbister, Lida Kanari, Daniel Keller, James King, Pramod Kumbhar, Samuel Lapere, Jānis Lazovskis, Huanxiang Lu, Nicolas Ninin, Fernando Pereira, Judit Planas, Christoph Pokorny, Juan Luis Riquelme, Armando Romani, Ying Shi, Jason P. Smith, Vishal Sood, Mohit Srivastava, Werner Van Geit, Liesbeth Vanherpe, Matthias Wolf, Ran Levi, Kathryn Hess, Felix Schürmann, Eilif B Muller, Henry Markram, Srikanth Ramaswamy
The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, interregional connectivity. We present a data-driven computational model of the anatomy of non-barrel primary somatosensory cortex of juvenile rat, integrating whole-brain scale data while providing cellular and subcellular specificity. The model consists of 4.2 million morphologically detailed neurons, placed in a digital brain atlas. They are connected by 14.2 billion synapses, comprising local, mid-range and extrinsic connectivity. We delineated the limits of determining connectivity from neuron morphology and placement, finding that it reproduces targeting by Sst+ neurons, but requires additional specificity to reproduce targeting by PV+ and VIP+ interneurons. Globally, connectivity was characterized by local clusters tied together through hub neurons in layer 5, demonstrating how local and interegional connectivity are complicit, inseparable networks. The model is suitable for simulation-based studies, and the model is made openly available to the community.