T.-K. Huang, Jheng-Syuan Shao, Alan Chuan‐Ying Lai, Ko-Chien Wu, Da-Fu Lin, Ya‐Jen Chang
Rationale: lung infection, aiming to elucidate its functional significance in shaping pulmonary immune responses and susceptibility to bacterial pneumonia. Methods: or LPS via intranasal administration to establish lung infection. We further performed bulk RNA sequencing and reanalyzed single-cell RNA sequencing datasets to dissect microbiota-immune interactions in the lung. Cellular assays, cytokine profiling, gene expression analysis, acetate supplementation, and conditional knockout mice were used to further elucidate the underlying mechanisms. Result: , and FFAR2 is likewise enriched in human AMs, underscoring translational relevance. Conclusion: via SCFA-FFAR2 axis, a protective network disrupted by lung dysbiosis. These findings highlight the therapeutic potential of SCFA-FFAR2 targeting.