Yi-Fan Zhou, Sibo Yang, Feng Zhang, Xiaodi Sun, Bo-Hao Chang, Ya-Nan Li, Jie-Hong Wu, Hui-Juan Jin, Ming Huang, Sheng-Cai Chen, Hang Yang, Dong-Ya Zhu, Bijoy K Menon, Bo Hu
Aberrant lactate metabolism not only serves as a prognostic biomarker but also provides a mechanistic link between metabolic insufficiency and epigenetic dysregulation through histone lactylation. Targeting the feedback loop involving H3K18la and ATF4-DDIT4 offers a promising therapeutic approach to limit cerebral edema and improve functional outcomes after ischemic stroke.