Bingchun Zeng, Kai Ling, Qingpeng Yuan, Zeyang Chen, Guangrong Zhang, Wenyue Kang, 旭光 鄭, Chuanghong Liao, Youqing Mai, Zhongjie Huang, Ruibin Huang, Tian‐Tian Zhai, Hongyan Jiang
This theranostic strategy suppressed primary and distant (abscopal) tumors, prevented recurrence, and established durable immune memory with low-dose irradiation. Our findings present a clinically translatable approach that combines a nanosensitizer with PARP inhibition to turn immunologically "cold" tumors into "hot" ones, thereby enhancing the efficacy of low-dose radioimmunotherapy while limiting systemic toxicity.