Lushuang Mao, Zhaofu Liao, Dong Tang, Yumin Qiu, Min Yang, Yanshang Li, Yituan Xie, Weimin Feng, Ze-jun Zheng, Xiaomeng Liu, Jiandong Ye, Shan-Shan Lu, Xin-bin Tang, Ming Shi, Yichen Qu, Heng Li, Zhixian Wu, Shun Xu, Xinguang Liu, Junjun Ding, Jian‐Jun Xie, Jun Tao, Xing‐dong Xiong
FOXP1 undergoes phase separation at its super-enhancer, recruiting transcription coactivators to form condensates. These condensates, in turn, facilitate binding with the SESN3 promoter and inhibit the mTORC1 signaling pathway, thereby delaying endothelial cell senescence.