Targeting the ARL4C/RAP1/PI3K-Akt-mTOR signaling loop promotes ARL4C ubiquitination and reverses oxaliplatin resistance in colorectal cancer
Yang Wang, Zewen Chang, Ziquan Sun, Lu Wang, Jingtao Li, Guodong Li, Yuliuming Wang, Jinning Zhang, Lianjie Ai, Zhongxu Zhang, Jiaojiao Dong, Ming Liu
原始摘要（英文原文）· Original abstract
Our study identifies ARL4C as a critical mediator of chemoresistance and metastasis in CRC. Targeting ARL4C with β-Lapachone restores oxaliplatin sensitivity and enhances therapeutic efficacy, offering a promising combinatorial strategy with strong potential for clinical translation in drug-resistant CRC.
Targeting the ARL4C/RAP1/PI3K-Akt-mTOR signaling loop promotes ARL4C ubiquitination and reverses oxaliplatin resistance in colorectal cancer — 科研速览 Science Skim